Parathyroidectomy

Overview

Thyroid Cancer Risk Factors

General Information

There are four parathyroid glands, two on each side of the thyroid.

  • Primary hyperparathyroidism is caused by a single bad parathyroid gland (or adenoma) 85% of the time, two parathyroid adenomas 10% of the time, or all four parathyroid glands (‘four gland hyperplasia’) 5% of the time.
    • For single and double parathyroid adenomas, the entire 1 or 2 parathyroid glands are removed.
    • For four gland hyperplasia, 3 and ½ of the glands are removed.
      ½ of a single gland is left behind to keep calcium levels in the normal range.
  • Kidney Related Hyperparathyroidism is caused by all 4 parathyroid glands every time and most commonly 3 and ½ of the glands are removed along with the cervical thymus.
    • Occasionally all four glands are removed, and a small amount of parathyroid tissue is implanted into a muscle to help keep calcium levels in the normal range.
      • For more details on surgical options for Kidney Related Hyperparathyroidism read here.

Before surgery:

  • A combination of ultrasound and 4D CT or Sestamibi SPECT imaging are used to identify how many parathyroid adenomas you have and where they are located.
  • To read more about imaging studies for Primary Hyperparathyroidis clck here.
  • When the parathyroid adenoma(s) can be identified prior to surgery, the surgeon can make a smaller incision (minimally invasive approach), focus dissection to certain areas limiting risk to other structures and allowing for a quicker / less painful recovery.
  • If the parathyroid adenoma(s) cannot be identified on imaging studies prior to surgery, this does not rule out the diagnosis of primary hyperparathyroidism or change the decision for surgery.
    • All 4 parathyroid glands are explored in this scenario to find which ones are bad.

During surgery:

  • Parathyroid adenomas are typically enlarged and have a different color / shape compared to a normal parathyroid gland.
  • Sometimes the appearance is not obvious and a small piece of the parathyroid gland in question can be sent to a pathologist to look at under a microscope (frozen biopsy) during the surgery to help tell the difference between normal and abnormal parathyroid glands.

A parathyroid adenoma is not a separate growth on the parathyroid gland, it forms inside the parathyroid gland and eventually replaces the entire gland.

The parathyroid cells that cause primary hyperparathyroidism and form a parathyroid adenoma make up > 95% of the cells in the involved parathyroid gland and it is impossible to preserve the few normal cells.

  • Therefore, the entire parathyroid gland is removed.

Parathyroid Hormone (PTH) has a very short half-life in the blood; it is rapidly removed by the kidneys and liver.

PTH levels are drawn on the morning of the surgery (baseline) and again 5, 10, and 15 min after the adenoma(s) is removed (while the patient remains asleep during the surgery).

  • The patient is considered cured if:
    • PTH levels drop > 50% of baseline.
    • Into the normal range (typically 15 – 85 pg / ml, varies by lab test).
    • Continued pattern of decline (continued decrease in value, no plateau or rise).
  • If these criteria is not met, the patient is not considered cured and the remaining parathyroid glands should be inspected to find the remaining bad glands.
  • Once the remaining bad parathyroid glands have been identified and removed, the PTH levels are checked again to ensure cure.

Prior to surgery, the normal parathyroid glands’ ‘teeter-totter’ function was working appropriately.

  • With high calcium levels they were producing little to no PTH.

As the calcium levels slowly fall back to normal range following surgery, the remaining parathyroid glands will resume their normal function.

  • Risk for temporary hypoparathyroidism (low PTH levels) resulting in hypocalcemia (low calcium levels).
    • Remaining parathyroid glands are sluggish to wake up following a long time of being inactive.
      • Increased risk with:
        • Double adenomas – only two remaining glands.
        • Extreme hypercalcemia prior to surgery – more likely to have been completely inactive and can take longer to wake up.
        • Underlying Secondary Hyperparathyroidism (sHPT):
          • Vit D deficiency, kidney disease, malabsorption, history of gastric bypass surgery, etc.
    • The remaining parathyroid glands’ function were temporarily compromised as the result of manipulation during the surgery.
      • Increased risk with 4-gland exploration and frozen biopsy interpretation.
    • Manifests clinically with numbness and tingling in the lips or fingertips in early stages or cramping in the hands or feet in later stages.
    • Treated with temporary over the counter calcium supplements.
      • For patients with history of gastric bypass, calcium citrate should be used instead of more commonly available calcium carbonate.

Occurs only in 5 % of pHPT.

The body needs some functioning parathyroid tissue to keep calcium levels in the normal range.

  • Removing all 4 glands would result in permanently low PTH levels (hypoparathyroidism) and as a direct result permanently low calcium level (hypocalcemia).
  • This would require daily calcium and Vit D supplementation, 2-3 times per day for the rest of the patient’s life.

Instead, 3 and ½ of the glands are removed (sub-total resection).

  • Leaving half of the most normal appearing gland with the best retained blood supply to ensure continued function.
  • Intraoperative PTH levels can still be used to ensure no rare 5th gland (~1% chance) or too large of a remnant gland being left behind.

~1% of risk of permanent hypoparathyroidism.

  • ½ remaining gland is not large enough or its blood supply was compromised, and it did not survive.

Most of the time it is not necessary to take calcium supplements following surgery.

Exceptions to this include:

  • If multiple parathyroid glands were removed and / or biopsied during the surgery.
  • If PTH levels dropped to very low levels during the surgery indicating the remaining parathyroid glands are sluggish to wake up and resume normal function.
  • The body takes time adjusting to normal calcium levels again after either very high calcium levels prior to surgery, or if calcium levels have been elevated for a very long time.

If you do need to take calcium following surgery, it is typically for a temporary period (weeks to months), and you will receive instructions for this when being discharged.

Patients are always counseled to watch for symptoms of low calcium which includes numbness and tingling in the lips / fingertips and cramping in the hands / feet.

  • If you ever experience this following surgery, please let Dr. Kay know.

There is a ~ 1% chance of one of the remaining parathyroid glands to turn into a parathyroid adenoma and cause a recurrence of primary hyperparathyroidism.

  • You will be routinely checked for this with standard blood work (basic metabolic panel which includes measuring Calcium levels) obtained during yearly physicals / follow-ups with your PCP.
  • There is no need to follow Parathyroid Hormone (PTH) levels long-term.
Parathyroidectomy

Frequently Asked Questions

The surgery is performed under general anesthesia in the operating room.

  • General anesthesia involves receiving medication through an IV which causes you to go completely asleep, then a breathing tube is placed through your mouth and down your windpipe to help you breathe while you are asleep.
    • A special type of breathing tube is used to help monitor the recurrent laryngeal nerve (controls voice and swallowing).
    • The breathing tube is removed before you wake up.

An incision is made low in the midline neck, in a natural horizontal crease of the skin.

  • If no natural crease is present, the incision is made in the natural hallow of the neck along the shirt collar line.
  • The incision is made in the midline which allows both sides to be explored.

The incision needs to be long enough in order to explore both sides.

  • Most incisions can be minimally invasive, ranging in size from 2 -3 cm (or ~ 1 inch).
  • Incisions may need to be longer if there is a large thyroid nodule or goiter on the same side as the suspected parathyroid adenoma, or if the patient has a larger neck requiring a deeper and more challenging dissection.

Surgery usually takes 1.0 – 1.5 hours.

  • Actual surgical dissection time is 15-20 min.
  • The remaining time includes waiting for PTH lab results and going to sleep / waking up.
  • Surgery times can be longer when multiple bad parathyroid glands are present.

So long as there are no pain or nausea issues in the recovery area, most surgeries can be done as an ‘outpatient’ where you go home the same day.

  • Exceptions include patients with significant health conditions, high risk for bleeding following surgery, live > 1 hour from the hospital, no one at home to help take care of the patient the first night after the surgery, or history of severe nausea following surgery.

It is not safe for you to drive home following general anesthesia.

Therefore, you should arrange for a ride to and from the hospital.

  • If you live alone, you should arrange for someone to stay with you the first night of your surgery due to the effects of anesthesia.
  • If you cannot arrange a ride to and from the hospital and/or someone to be with you the night of the surgery, you will need to spend the night in the hospital.

Typically the entire day lasts ~ 6 hours.

  • Arrive 2 hours prior to surgery.
  • Length of surgery plus time to put you to sleep and wake you up, ~ 2 hours.
  • 2 hours recovering.

1 hour after surgery, you are transferred to your hospital room where your family and/or friends can see you.

The nursing staff takes care of you overnight.

Dr. Kay and his team see you the following morning and you are usually ready to be discharged home by 10:00 am provided your recovery is going as expected.

If for any unexpected reason you need to spend the night, your insurance company will pay for a 23-hour observation period at no extra cost to you.

  • This is included in the pre-authorization approval for the surgery.

A drain is a small rubber tube placed in the neck connected to a suction bulb.

  • It sucks out any fluid or blood that can develop following surgery as the result of the dissection and removal of the parathyroid gland(s).

Most surgeries do not need a drain placement.

Exceptions to this include:

  • Increased risk for bleeding based on the need from blood thinners that could not be stopped before or after surgery (for 5 days).
  • Obese patients with increased risks for developing a seroma.

If you receive a drain, you can go home with it and Dr. Kay’s office will arrange for an appointment to have this removed in the office 1-2 days following surgery.

  • The drain can get wet in the shower.
  • The nursing staff will show you how to take care of the drain before you leave the hospital.
  • You will be instructed to record how much fluid is coming out of the drain and bring this with you to your appointment.

If you spend the night in the hospital, on most occasions the drain can be removed the following day before you are discharged home.

Dr. Kay calls you with the pathology report 2-3 business days following the surgery.

  • 99.9% of the time parathyroid adenomas a benign (not cancerous).

When you schedule surgery, a post-operative appointment will also be scheduled for you ~ 6 weeks following your surgery.

Yes, in order to confirm that you are cured, Dr. Kay’s office will contact you several days before your appointment date with instructions to get blood work done that measures your calcium and PTH levels.

  • It is important that this blood work is done before your appointment so that Dr. Kay can review the results with you.
  • You do not need to be fasting for this blood work.

No. While the thyroid gland is manipulated in order to gain access to the parathyroid glands, short and long-term function of the thyroid are not affected.

  • The very rare exception to this is when the parathyroid adenoma is located inside the thyroid gland (‘intrathyroidal parathyroid adenoma’) requiring a hemithyroidectomy (removing half of the thyroid) at the same time.
    • In this rare scenario, 30% of the time the patient may require a once daily thyroid hormone medication for the rest of their life.

You need a physical performed by your primary care provider to clear you prior to surgery.

If you see a sub-specialist for a significant medical issue like a cardiologist or pulmonologist, Dr. Kay will ask you to be cleared by this specialist as well.

If you are on a blood thinner, Dr. Kay will ask you to get permission to stop this blood thinner for the appropriate amount of time before surgery (varies by medication type) and for 5 days following surgery as well.

  • If you are unable to come off the blood thinner, you will likely need to have a drain placed and stay the night in the hospital (see above).

What to Expect Following Surgery

You can expect to experience pain and swelling around the incision lasting up to 5 days.

  • Mild bruising may also be expected which will resolve over the course of 1 – 2 weeks. This bruising may travel down the front of the chest due to gravity before it fully resolves.

You can also expect to experience a sore throat and hoarse voice lasting up to 1 week.

  • There are no voice restrictions during this period.

Everyone experiences pain in different ways and has different pain thresholds, therefore your experience may differ to some extent.

For 24 hours: Limit your activity for the first 24 hours following surgery and get plenty of rest as you recover from general anesthesia.

For 1 week: No heavy lifting or pushing (> 10lbs), active sports (e.g., running or jumping), strenuous exercise, heavy household work, or any activities that elevate your heart rate or blood pressure in order to reduce the risk of bleeding in your neck. Objects that cannot be lifted with one hand are considered too heavy.

  • You may walk at a normal pace and do light household activities during the first week.

There are no activity restrictions after 1 week.

In general, you may plan to return to work in 1 week, 2 weeks if your job requires manual labor, or as otherwise instructed.

Due to the sore throat caused by the breathing tube and surgical dissection, we recommend starting with liquids and soft foods.

You may progress to solid foods (your normal diet) as tolerated; this may take 1 – 2 days.

There are no restrictions in the positioning of your head and neck following surgery. You may relax and sleep in whatever position that is comfortable for you.

  • No need to sleep with your head elevated.

It is not uncommon for your sleep cycle to be affected by general anesthesia. Do your best to resume normal sleep patterns and avoid excessive daytime napping following the initial 24-hour rest period.

You can drive once you are off the strong (prescription) pain medication and when you can turn your head / neck to check your blind spots without hesitating. This may take 1-2 days.

Your incision was closed in two layers:

  • Deep stitches which will dissolve on their own over the course of 8 – 10 weeks.
  • A superficial layer of blue skin glue and strips of white bandages (steri-strips) embedded in the glue.

You may bathe or shower as soon as you like after surgery.

  • It is ok to allow soap and water to run over the bandage.
  • Do not submerge under water for extended periods of time (> 1 min).
  • Do not scrub the incision; pat it gently dry with a towel afterwards.

If the glue and bandage is still present 2 weeks after surgery, you may peel off the bandage (Steri-Strip) and the rest of the glue.

  • It is ok if the bandage comes off before two weeks. No need to cover the incision.
  • If the white bandages start to curl off the skin before two weeks, you may carefully use scissors to trim the curled edges.

After the bandage comes off, you may notice several small bumps under the skin along your incision line and the incision line may appear raised.

  • The bumps are the deep stitches that have yet to dissolve (this can take up to 8 – 10 weeks).  They will dissolve with time / massages (see below) and the incision will eventually heal flat.
  • If there are any concerns with the appearance of your incision once the bandage comes off, please take a picture and send it to Dr. Kay via MyChart messaging.

As your incision heals, it is not uncommon to experience sensations of tingling, burning, itching, or pinching / shooting pains.

  • These sensations are completely normal and indicate appropriate healing of the sensation nerve fibers in your neck.
  • These sensations will resolve over the course of several weeks to several months.

Once the bandage is off, please purchase over the counter Vitamin E oil from a pharmacy or supermarket (Vitamin E oil capsule which can be broken open are an acceptable alternative).

  • Use the oil to massage your wound with the pads of your fingers, using a slow circular motion, as deep as you can tolerate.
  • Perform this twice per day for 5 minutes at a time, for 1 month. You may massage more frequently or for longer periods.
  • You may also use different kinds of scar ointments / creams such as Mederma, Biocorneum, etc. or silicone strips.
    • The important thing is that you do the massages as instructed above.

Once the bandage is off, please keep your incision out of direct sunshine for the first 3 months after surgery (using shade, a scarf, and/or sunscreen with SUV 30 or higher with both UVA and UVB protection) in order to prevent discoloration of the scar.

Pain control:

Ice compresses can help to treat swelling and pain around the incision. Apply for 10 min at a time. You can repeat every 30 minutes as needed.

Sore throat lozenges (particularly those with the active ingredient ‘Benzocaine’ such as found in Cepacol lozenges) will help to treat the discomfort deep in your throat.

Drinking fluids frequently will help the small scratches inside the throat caused by the breathing tube to heal more quickly and also relieve your pain faster.

Over the counter Tylenol (acetaminophen) can be taken every 6 hours as needed for pain relief, up to 1,000 mg each dose, do not exceed 4,000 mg total in 24 hours. Do not take 3,000 mg total per day for > 3 consecutive days.

Over the counter NSAID’s (Non-Steroidal Anti-Inflammatory Drugs)

  • Ibuprofen, Motrin, or Advil can be taken every 6 hours as needed for pain relief, up to 400 mg each dose, do not exceed 1,600 mg total in 24 hours. Do not take more than 1,200 mg total per day for > 3 consecutive days.

OR

  • Aleve (naproxen) can be taken every 12 hours as needed for pain relief, up to 550 mg each dose, do not exceed 1,100 mg total in 24 hours. Do not take 1,100 mg total per day for > 3 consecutive days.
  • These NSAID’s can be alternated with Tylenol as in the below examples:
    • 500 – 1,000 mg of Tylenol every 6 hours, alternating and staggering with Ibuprofen 200 – 400 mg every 6 hours (essentially taking pain medication every 3 hours as needed).
    • 500 – 1,000 mg of Tylenol every 6 hours, alternating and staggering with Aleve 225 – 550 mg every 12 hours.

In situations when the above pain control regimen does not control your pain symptoms adequately, you were prescribed 5 tablets of a low dose narcotic medication (either Tramadol or Hydrocodone / Acetaminophen).

  • You can take 1-2 tablets of this every 6 hours as needed for pain control.
  • If required, these prescription pain medications are not usually needed for more than 24 hours after surgery.
  • If you were prescribed Hydrocodone / Acetaminophen, please do not take any additional Tylenol or Acetaminophen at the same time.
  • These medications may cause you to be drowsy. Do not drive / operate heavy machinery, drink alcohol, or take any other sedating medications while using the prescription narcotic pain medication.

Calcium

Sometimes following cure of primary hyperparathyroidism, it takes time for the remaining normal parathyroid glands to start working again. As a result, there is a small risk of developing temporary low calcium until these parathyroid glands have regained their function.

To prevent against this, please take ~ 1,000 mg of an over the counter calcium supplement three times per day for 1 week, the 1,000 mg twice per day for 1 week, then 1,000 mg once per day for 1 week, then discontinue unless otherwise directed by Dr. Kay.

  • IT IS VERY IMPORTANT THAT YOU START THE CALCIUM ON THE DAY OF YOUR SURGERY AND TO DO YOUR BEST TO GET ALL THREE DOSES IN ONCE YOU ARE HOME.
  • Most calcium supplements are large pills which may be painful to swallow following surgery. For this reason we recommend purchasing a chewable calcium supplement in a gummy form or TUMS (which has calcium in it).
  • Dosage of calcium supplements vary; it is ok if you take more than 1,000 mg per dose based on the calcium supplement you purchased.

Please watch out for symptoms of low calcium which include numbness and tingling in the lips / fingertips or cramping in the hands / feet (if this occurs, it will usually happen ~ 36-48 hours following surgery).

  • If you experience any of these symptoms, please start taking 1,000 mg of calcium every 30 minutes and let Dr. Kay know. He will provide you with further instructions moving forward.

Vitamin D

If you were instructed to take an over the counter or prescription Vitamin D supplement before surgery, please continue taking this until your follow-up appointment with Dr. Kay.

Anti-Nausea Medication

If you are discharged home on the same day of surgery, you will be given an antinausea prescription called Zofran (ondansetron). This comes in a tablet form that dissolves underneath your tongue.

You can use this as needed if you are experiencing nausea. Please have a low threshold to use this in order to prevent vomiting (which can increase the risk of bleeding in your neck).

Stool Softener

You will receive narcotics as part of your general anesthesia on the day of surgery and you may also take a prescription narcotic pain medication following surgery. These narcotic medications can cause constipation.

In order to prevent this, you may consider purchasing an over-the-counter stool softener (such as docusate or senna) and take for 24-48 hours following surgery as directed on the package (especially if you are prone to constipation).

  • If you remain constipated for > 48 hours after surgery despite the use of a stool softener, you may purchase a bottle of over-the-counter magnesium citrate and take as directed. If your constipation persists despite this, please contact the office for further instructions.

Prior Medications

You should resume taking all other medications the day after surgery, unless instructed otherwise by your primary care provider.

Blood Thinning Medications

If you were on any blood thinners (Plavix, Coumadin, Eliquis, Xarelto, Aspirin, etc.) prior to surgery, please do no restart the medication until 5 days after your surgery to limit the risk of bleeding, unless instructed otherwise.

Due to the effects of the breathing tube being placed during surgery, you may experience thick mucus in your throat for 24-48 hours. It is ok to gently clear your throat and cough to clear this mucous.

If the sensation of mucous in your throat persists for > 48 hours, it is usually not because there is still mucous there. At this point, persistent inflammation and sensitivity of the vocal cords caused by the breathing tube can mimic the sensation of mucous and is best treated by drinking plenty of liquids, using over the counter throat lozenges with the active ingredient ‘Benzocaine’ such as found in Cepacol lozenges, and avoiding further throat clearing / coughing.

  • Clearing your throat / coughing may cause your throat symptoms to worsen or persist, similar to scratching a mosquito bite.

Swelling beneath or near your incision site, particularly if it is visibly noticeable and/or causing pressure in the neck.

  • Please call the office at 630.938.6161 and if possible, send a picture of your incision (one from directly in front of you and one from the side) via MyChart messaging.

If you notice rapid and progressive swelling in your neck, or bleeding from your incision, please call 911 as this could represent a hematoma, or active bleeding in the neck, and this is a medical emergency.

If you notice redness and itching around the bandage, especially if starting 24-48 hours after surgery, you may be experiencing an allergic reaction to the skin glue or the white steri-strip bandages.

  • For this you can try taking over the counter Benadryl as directed on the package. If the symptoms do not resolve, please call the office at 630.938.6161 for further instructions as the bandage and glue may need to be removed.

Please record your drain output twice daily.

OK to get the drain wet in the shower.

Dr. Kay’s office will call to arrange drain removal 1-2 days following your surgery.

  • If the drain output is > 50 cc or ml in a 24-hour period, please call the office at 630.938.6161 before coming to your appointment. In this scenario, the drain may need to stay in place longer.

When surgery is scheduled, an appointment should have been made for you to follow-up ~ 6 weeks after surgery.

Central Neck Dissection

Risk of injury to the Recurrent Laryngeal Nerve

This nerve travels just behind the thyroid gland and enters the larynx (voice box) very close to where the thyroid gland attaches to the trachea (windpipe).

This nerve controls the movement of the vocal cord on that side, helping to produce your voice and assist in swallowing.

  • There is a 5% chance that this nerve is overmanipulated, stretched, or overheated by an instrument during surgery resulting in a temporary weak and hoarse voice that could last several days, sometimes up to 9 months.
  • There is a 1% chance that the nerve is severely injured and never recovers or cut (either accidentally or to remove cancer that is wrapping around the nerve). This could result in a permanently weak and hoarse voice.
    • Young and healthy patients can sometimes learn to compensate with the other vocal cord (with or without the help of a speech therapist) to the point where they are happy with their voice.
    • Otherwise, a second surgery can be performed (called a thyroplasty) to bring the voice back to very close to normal: conversational voice is typically the same, but singing and yelling will always be off.
  • If both nerves are injured during the surgery, it could cause significant difficulty breathing and the need for a tracheotomy tube (temporary or permanent) in the neck to save the patient’s life.
    • With the use of a special breathing tube during the surgery that allows the surgeon to monitor the function of the recurrent laryngeal nerve, the risk of a tracheotomy tube can be completely removed.
    • If during a parathyroidectomy both sides need to be explored, after completing dissection on the first side, the nerve on that side is stimulated and if it responds appropriately indicating the nerve is still working, it is safe to proceed to the other side for exploration.
      • If the nerve does not stimulate, the other side will not be explored, and the surgery will stop there.
      • The patient is then woken up and a second stage surgery will be performed at a later date once the recurrent laryngeal nerve has recovered.
        • While a two-stage surgery is not ideal, it is much better than putting the patient at risk of needing a tracheotomy tube.
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Risk of no cure

There is a ~ 1% risk of not being able to find all the bad parathyroid glands during surgery and thus not being able to cure the patient.

Sometimes the bad parathyroid glands can be very small and hide in difficult to find locations.

To limit this risk of not curing the patient during surgery, multiple imaging studies are obtained to find the number of bad glands and their locations prior to surgery, intraoperative PTH measurements are performed during surgery to ensure cure prior to waking the patient up, and special dissection techniques are used to search for parathyroid glands when they may be located in atypical locations.

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Risk of causing the opposite problem – low calcium levels (hypocalcemia)

If all four parathyroid glands are removed or injured, it can result in temporary or permanently low calcium levels (hypocalcemia) requiring calcium and Vitamin D supplements 2-3 times per day, every day for the rest of the patient’s life.

The main scenario where this would occur is if all 4 parathyroid glands are bad (occurs ~ 5% of the time).

  • In this situation you do not remove all 4 of the parathyroid glands because the body needs some functioning parathyroid tissue to keep calcium levels in the normal range.
  • Instead, 3 and ½ of the glands are removed.
  • The ½ gland left behind should be enough to keep the calcium in the normal range, but not too much for it to potentially cause primary hyperparathyroidism again in the future.
  • Sometimes the ½ gland left behind is too small or was injured and never recovered after being cut in half. This would result in permanently low calcium levels.

The risk for permanently low calcium levels following parathyroidectomy surgery is 1%.

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Risk for temporary low calcium levels (hypocalcemia)

There is a ~10% risk of this happening after any parathyroidectomy surgery for two main reasons:

  • The remaining parathyroid glands are sluggish to wake up following a long time of being inactive.
    • Increased risk with:
      • Double adenomas – two glands were removed, now only two glands remain.
      • Extreme hypercalcemia (>12.0) prior to surgery – normal glands are more likely to have been completely inactive and can take longer to wake up.
      • Underlying Secondary Hyperparathyroidism (sHPT):
        • Vit D deficiency, kidney disease, malabsorption, history of gastric bypass surgery, etc.
    • The remaining parathyroid glands’ function were temporarily compromised as a result of manipulation during the surgery.
      • Increased risk with 4-gland exploration and frozen biopsy interpretation.
  • To prevent temporary low calcium, patients are routinely instructed to take over the counter calcium supplements for a 3-week period following surgery.
    • More details found in the “What to Expect Following Surgery” section above.
Key Factors to Consider

Elevated Risks in Parathyroidectomy Surgery

  • Hashimoto’s thyroiditis or Grave’s disease are also present.
  • With revision surgery (when prior surgery has been performed in the front of the neck – for the thyroid or parathyroid, anterior cervical spine surgery, or previous tracheotomy).
  • Thyroid cancer is also present.
  • When large goiters or substernal goiters (extension down into the chest) are present.
  • In morbidly obese patients.

For all parathyroid surgery, surgical outcomes / cure rates are the highest and complication rates are the lowest when surgery is performed by a high-volume surgeon (> 50 parathyroidectomy surgeries per year).

Central Neck Dissection

What are the risks for all surgeries

Pain following surgery typically lasts up to 3-5 days and is usually tolerated with little to no narcotic use (see more information in the ‘What to Expect Following Surgery’ section).

There is very low risk (~1 %) for infection following hemithyroidectomy.

Antibiotics are given to you during surgery, but none are routinely used following surgery.

  • Signs of infection include redness and swelling near the incision, worsening pain, and fever.

There is a 1% chance of significant bleeding following surgery.

Signs of bleeding include significant swelling in the front of the neck, similar to the appearance of a bullfrog.

Sometimes this bleeding stops on its own, other times it does not and it can be life threatening requiring urgent surgery to stop the bleeding.

  • This is why activity levels are restricted for 1 week following surgery (see more in the ‘What to Expect Following Surgery’ section.

Risks for bleeding are higher when a patient cannot be taken off their blood thinners completely.

  • In this scenario the patient will be watched closely overnight in the hospital and a drain will be placed to limit this risk.

You are required to be cleared by your primary care provider prior to surgery and any other sub-specialty providers who provide care for important medical conditions.

  • In general, the risks of anesthesia are higher with age and presence of significant medical conditions.
  • Your anesthesiologist will discuss these risks with you in detail on the day of your surgery.

The incision is made as small as possible (based on thyroid lobe size and the patient’s anatomy) and attempted to be hidden in a natural skin crease (if present) or hollow of the neck.

Ultimately it is up to how your body heals (based on previous incisions or scar).

Typically, incisions in the neck heal very nicely.

If there is a history of keloid formation, a steroid called Kenalog may be injected into the skin at the time of surgery to lower the risk of keloid formation as best as possible.

Central Neck Dissection

Revision Parathyroidectomy


Surgery is considered a revision parathyroidectomy when:

  • A previous parathyroidectomy surgery has been performed but:
    • The patient was never cured.
    • The patient was cured for a period of at least 6 months, but later developed primary hyperparathyroidism again (from a different parathyroid gland).
  • A previous thyroidectomy (hemi or total) has been performed.

When either of these surgeries has been performed in the past, it presents unique risks when performing a revision parathyroidectomy:

  • Scar tissue will be present from the prior surgery which complicates the surgical dissection and increases the risk of injury to nearby important structures.
    • The risk to injuring the Recurrent Laryngeal Nerve controlling your voice and swallowing is roughly doubled:
      • 10% (from normally 5%) for temporary weak and hoarse voice lasting days, sometimes up to 9 months.
      • 2% (from normally 1%) for permanently weak and hoarse voice.

There could have been injuries to nearby structures during the previous surgery.

  • If the recurrent laryngeal nerve was permanently damaged on one side during the previous surgery, injury the opposite recurrent laryngeal nerve during a revision parathyroidectomy could result in significant difficulty breathing and the need for a tracheotomy tube (temporary or permanent) in the neck to save the patient’s life.
    • Therefore, even if the patient’s voice sounds normal following the first surgery, a flexible laryngoscopy (fiberoptic camera exam to evaluate the vocal cords) is essential to perform before a revision parathyroidectomy to ensure that there is no permanent vocal cord paralysis from the first surgery.
    • If vocal cord paralysis is discovered, the decision to perform a revision parathyroidectomy must be very carefully made between the patient and surgeon, understanding the very real risk of requiring a tracheotomy tube.
  • During the previous surgery, parathyroid glands may have been purposefully removed to try to cure the patient, accidentally removed (sometimes noted in the pathology report), and/or damaged.
    • This means that there may be fewer functioning parathyroid glands present, and the risk for damaging or removing all remaining parathyroid glands resulting in permanently low calcium levels is much higher than a typical parathyroidectomy.
      • The risk for permanently low calcium for a standard parathyroidectomy is ~1%, but for revision parathyroidectomy it may range from ~ 2 – 5% depending on how many parathyroid glands were previously removed / injured.

Kidney Related Hyperparathyroidism


Parathyroidectomy for renal hyperparathyroidism is unique to standard parathyroidectomy in several notable ways:

  • The risk for developing severe hypocalcemia (low calcium) following surgery is much higher.
  • Therefore, surgery is always performed as an inpatient, involving a stay in the hospital that could last 1-5 days until calcium levels have normalized.
  • In order to treat the hypocalcemia, calcium must be given via oral supplements and also possibly continuously via an IV directly into the blood.
    • A special type of IV called a central line must be placed to continuously give calcium directly into the blood.
    • Placing a central line may be done during the parathyroidectomy surgery by the anesthesiologist, or before surgery by an interventional radiologist.
    • This central line will be removed prior to being discharged from the hospital.
  • In order to monitor calcium levels very closely and make appropriate changes to the amount calcium given, the patient is often admitted to the ICU (Intensive Care Unit) initially following surgery.
    • The amount of time spent in the ICU varies but may take 1-3 days.
  • Other doctors will be consulted during the hospitalization to help control the hypocalcemia.
    • This may include an Intensive Care Doctor, Nephrologist (kidney doctor), and/or Endocrinologist (hormone specialist doctor).
  • If the patient is currently on dialysis, a surgical drain is placed to help limit the risk for bleeding following surgery, given the need for blood thinners being used during dialysis.
    • The drain is typically removed before the patient is discharged home.
  • To read more about this, visit the page Parathyroidectomy for Kidney Related Hyperparathyroidism.

To learn more about all Thyroid and Parathyroid Surgeries click here.

To learn more about the Thyroid return to the Thyroid home page here.

To learn more about the Parathyroid return to the Parathyroid main page here.

How Do I Schedule Surgery?

You can call 630.938.6161 and ask to speak to the surgery scheduler
to find a date that works well for you and Dr. Kay.